Monoacylglycerol lipase modulators

US11708359B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Michael K. Ameriks · San Diego, US
• Cynthia B. Berry · Poway, US
• Pablo Garcia-Reynaga · San Diego, US
• Brian Ngo Laforteza · San Diego, US
• Jimmy T. Liang · San Diego, US

Key dates

• Filing date: Feb 9, 2021
• Grant date: Jul 25, 2023
• Expiry date: Feb 9, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3.1.0 and 4.1.0 Azabicycle compounds of Formula (I), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein X, Y, R1, R2a, and R2b are defined herein.