Immunoglobulin variable domains

US11708404B2 · kind B2 · utility

Assignees

• Ablynx N.V. · BE
• Sanofi · FR

Inventors

• Marie-Ange Buyse · Merelbeke, BE
• Carlo Boutton · Wielsbeke, BE

Key dates

• Filing date: Apr 13, 2022
• Grant date: Jul 25, 2023
• Expiry date: Apr 13, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/31
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

VH domain, in which: (i) the amino acid residue at position 112 is one of K or Q; and/or (ii) the amino acid residue at position 89 is T; and/or (iii) the amino acid residue at position 89 is L and the amino acid residue at position 110 is one of K or Q; and (iv) in each of cases (i) to (iii), the amino acid at position 11 is preferably V; and in which said VH domain contains a C-terminal extension (X)n, in which n is 1 to 10, preferably 1 to 5, such as 1, 2, 3, 4 or 5 (and preferably 1 or 2, such as 1); and each X is an (preferably naturally occurring) amino acid residue that is independently chosen, and preferably independently chosen from the group consisting of alanine (A), glycine (G), valine (V), leucine (L) or isoleucine (I).