RNA interference delivery formulation and methods for malignant tumors
US11708575B2 · kind B2 · utility
0Cited by
2References
17Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 15, 2019 |
| Grant date | Jul 25, 2023 |
| Priority date | — |
| Expiry date | Nov 15, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y205/01018
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides formulations for use in distributing RNAi molecules targeted to a human GST-π for treating a malignant tumor in a subject. The formulation can include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product can be made by lyophilization of the formulation. This invention further provides methods for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing the RNAi agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.