Self-actuating articles

US11712421B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Carlo Giovanni Traverso · Newton, US
• Alex G. Abramson · Chesterfield, US
• Ester Caffarel Salvador · Cambridge, US
• Niclas Roxhed · Cambridge, US
• Minsoo Khang · Boston, US
• Taylor Bensel · Walpole, US
• Robert S. Langer · Newton, US

Key dates

• Filing date: May 17, 2018
• Grant date: Aug 1, 2023
• Expiry date: Apr 9, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/0509
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).