Inhibitors of lysyl oxidases
US11712437B2 · kind B2 · utility
0Cited by
0References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 13, 2022 |
| Grant date | Aug 1, 2023 |
| Priority date | — |
| Expiry date | Mar 13, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/42
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are novel compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 μM, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.