Chimeric polypeptide assembly and methods of making and using the same
US11713358B2 · kind B2 · utility
3Cited by
94References
72Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 26, 2016 |
| Grant date | Aug 1, 2023 |
| Priority date | — |
| Expiry date | Jan 2, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2523/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.