System and method for cell and tissue preparation

US11713442B2 · kind B2 · utility

Assignee

• DEKA Products Limited Parternship · US

Inventors

• Richard E. Andrews · Manchester, US
• Stephanie M. Miskell · Weare, US
• Zachary Kops · Andover, US
• Justin M. Ferrentino · Mont Vernon, US
• Michael C. Tilley · Amherst, US
• Andrew K. Capulli · Billerica, US
• Keira L McGrath · Manchester, US
• Stuart Alexander Jacobson · San Francisco, US

Key dates

• Filing date: Jun 17, 2020
• Grant date: Aug 1, 2023
• Expiry date: Jun 10, 2041

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/06
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Manufacturing system and method for creating multiple tissue constructs from cells. System can include a thaw subsystem (if the cells are provided in a frozen state), an expansion subsystem, a concentration subsystem, and a tissue maturation subsystem. Each of these subsystems is modular and can be reconfigured, and the process can be repeated depending on the specific tissue process being implemented. Multiple tissue types can be combined in multiple bioreactors. The activities of multiple bioreactors can be coordinated and controlled in an automated manner by a supervisor controller. The supervisor controller can receive user input at the start of the process, and can manage the process henceforth, alerting the user if user actions are required.