Point-of-care apparatus and methods for analyte detections using electrochemical impedance or capacitance

US11714083B2 · kind B2 · utility

Assignees

• ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · US
• Mayo Foundation for Medical Education and Research · US
• AXIM BIOTECHNOLOGIES. INC. · US

Inventors

• Jeffrey LaBelle · Tempe, US
• Garrett Repp · Gilbert, US
• Chi Lin · Vega, US
• Mark Spano · Laurel, US
• Jennifer Blain Christen · Chandler, US
• Hongwu Jiang · Chandler, US
• Marcus Smith · Birmingham, US
• Andrew Penman · Birmingham, US
• Pierce Youngbar · Birmingham, US
• Mackenzie Honikel · Chandler, US
• Curtiss Cook · Scottsdale, US

Key dates

• Filing date: May 4, 2018
• Grant date: Aug 1, 2023
• Expiry date: Oct 24, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/075
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.