Method for early diagnosis of keratoconus based on multi-modal data

US11717151B2 · kind B2 · utility

Assignees

• SHANGHAI MEDIWORKS PRECISION INSTRUMENTS CO., LTD. · CN
• EYE AND ENT HOSPITAL OF FUDAN UNIVERSITY · CN

Inventors

• Yang Shen · Shanghai, CN
• Xingtao Zhou · Shanghai, CN
• Huijie LI · Shanghai, CN
• Chongyang Wang · Hejian, CN
• Wenguang Chen · Hunan, CN
• Jing Zhao · Shanghai, CN
• Meiyan Li · Shanghai, CN
• Yiyong Xian · Shanghai, CN
• Haipeng Xu · Ji'an, CN
• Lingling Niu · Beijing, CN
• Wuxiao Zhao · Shanghai, CN
• Tian Qi Han · Shanghai, CN

Key dates

• Filing date: Aug 5, 2021
• Grant date: Aug 8, 2023
• Expiry date: Aug 5, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30041
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

A method for early diagnosis of keratoconus based on multi-modal data considers a mutual relationship between both eyes using four refractive maps for corneas of the both eyes and absolute corneal elevation data, and combines the deep convolutional network method, the traditional support vector machine (SVM) method in machine learning, and the elevation map enhancement method with adjustable best-fit-sphere (BFS) to identify sensitivity and specificity of a focus and balance the sensitivity and specificity. With multi-dimensional comprehensive judgment of a keratoconus morbidity with a patient as a unit, combined with binocular data including both manual selection features and deep network learning from big data, the diagnosis method has higher robustness and accuracy.