Patent · US Active

Interleukin 15 protein complex and use thereof

US11717559B2 · kind B2 · utility

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15Claims

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Assignees

Inventors

Xiangdong QU · Shanghai, CN
Xin Ye · Beijing, CN
Qiyue Hu · Shanghai, CN
Dongbing Cui · Shanghai, CN
Weikang Tao · Shanghai, CN
Lianshan Zhang · 安丰镇, CN
Piaoyang Sun · Lianyungang, CN

Key dates

Filing date	Dec 21, 2020
Grant date	Aug 8, 2023
Priority date	—
Expiry date	Jan 5, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

An interleukin 15 (IL-15) protein complex is provided. The IL-15 protein complex includes soluble fusion proteins (I) and (II), wherein the fusion protein (I) is an IL-15 polypeptide or a functional fragment thereof, and the soluble fusion protein (II) is an IL-15Rα polypeptide or a functional fragment thereof. The soluble fusion protein (I) has at least one amino acid residue mutated to a cysteine (Cys) residue, which pairs with a corresponding mutated Cys residue on the soluble fusion protein (II), or vice versa, to form one or more disulfide bonds. The IL-15 protein complex can be used for tumor therapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.