Patent · US Active

Near-infrared fluorescent molecule active targeting folate receptor and preparation method thereof

US11718625B2 · kind B2 · utility

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3Claims
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Key dates

Filing dateNov 27, 2020
Grant dateAug 8, 2023
Priority date—
Expiry dateNov 27, 2040

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC09K2211/1059
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present disclosure relates to the fields of near-infrared surgical navigation fluorescent molecules, cell marker imaging and so on, and in particular discloses an active targeting near-infrared fluorescent small molecule structure and a preparation method thereof. The present disclosure prepares the active targeting near-infrared fluorescent small molecule with pemetrexed disodium and derivatives thereof as active targeting groups by utilizing an organic total synthesis method. Such active targeting near-infrared fluorescent molecule has the advantages of high active targeting property, strong specificity, good water solubility, high fluorescence quantum yield and so on.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.