Compositions and methods for targeting stromal cells for the treatment of cancer
US11718685B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | May 20, 2019 |
| Grant date | Aug 8, 2023 |
| Priority date | — |
| Expiry date | Aug 19, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10343
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.