Multicontrast synthetic late gadolinium enhancement imaging using post-contrast magnetic resonance fingerprinting

US11719778B1 · kind B1 · utility

Assignees

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US
• CASE WESTERN RESERVE UNIVERSITY · US
• UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER · US

Inventors

• Jesse Hamilton · Cleveland Heights, US
• Imran Rashid · Sydney, AU
• Nicole Seiberlich · Cleveland Heights, US
• Sanjay Rajagopalan · Columbus, US

Key dates

• Filing date: Jan 31, 2022
• Grant date: Aug 8, 2023
• Expiry date: Jan 31, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/5614
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods and systems generate synthetic late gadolinium enhancement (LGE) magnetic resonance images using a magnetic resonance fingerprinting (MRF) acquisition. From a single acquisition, MRF image data is obtained, including co-registered T1 and T2 tissue property maps. Different tissue regions of interest are identified, such as viable myocardium, scar, and blood and T1 and T2 values for each are determined. Based on these, different sets of pulse sequence parameters are determined, e.g., using different synthetic image contrast models receiving the MRF image data. Synthetic LGE images at different contrasts are generated as a result, including a synthetic bright-blood LGE image, a synthetic dark-blood/gray-blood LGE image, and a synthetic optimized imaged.