Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto

US11723914B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Mark H. Schoenfisch · Chapel Hill, US
• Lei Yang · Newton, US

Key dates

• Filing date: Mar 28, 2018
• Grant date: Aug 15, 2023
• Expiry date: Mar 28, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/234
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are hyperbranched polyaminoglycosides, where in some embodiments, the hyperbranched polyaminoglycosides are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of hyperbranched polyaminoglycosides. In some embodiments, the covalently modified hyperbranched polyaminoglycosides may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both gram positive and gram negative bacteria as well as other microbes.