Patent · US Active

Microparticle-based enzyme systems for selective removal of target molecules

US11723958B2 · kind B2 · utility

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2References
9Claims
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Inventors

Key dates

Filing dateApr 21, 2020
Grant dateAug 15, 2023
Priority date—
Expiry dateApr 21, 2040

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Y305/04001
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present disclosure provides compositions of microparticles and uses thereof for removing toxic or undesirable molecules from an environment, e.g. the blood of a subject. The microparticles can be liposomes. In one embodiment, the aqueous phase of the liposomes contains (i) a system of generating NAD+ from NADH, and (ii) one or more enzymes that are involved in one or more NAD+-dependent reactions that remove the toxic or undesirable molecules from the environment. In one embodiment, the liposomes contain NADH oxidase, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) to remove ethanol from the blood of a subject.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.