Polyheterocyclic compounds as METTL3 inhibitors
US11725010B2 · kind B2 · utility
2Cited by
4References
3Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 29, 2022 |
| Grant date | Aug 15, 2023 |
| Priority date | — |
| Expiry date | Jul 29, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.