Graphene oxide-based nanolab and methods of detecting of exosomes
US11726086B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 25, 2020 |
| Grant date | Aug 15, 2023 |
| Priority date | — |
| Expiry date | Jan 20, 2042 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0887
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A graphene-based sandwich immunoassay for detecting whether a target biological substance is present in a sample, generally comprising contacting said sample with a plurality of particles coated with graphene nanosheets, each particle having at least one targeting receptor, such that the target biological substance, if present, associates with the targeting receptor, and detecting the presence of the target biological substance in the sample by subsequently contacting the sample with a detection antibody, wherein the detection antibody is capable of targeting and binding with the target biological substance if bound to the targeting receptor to yield a detectable complex. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.