Neuromodulation based adaptive controller for mitral stenosis
US11728040B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 14, 2021 |
| Grant date | Aug 15, 2023 |
| Priority date | — |
| Expiry date | Aug 15, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/36114
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
This disclosure provides a simulation platform to study and perform predictive analysis on valvular heart disease, Mitral stenosis (MS) and provides a control approach to correct hemodynamic imbalances during MS conditions. Conventional approaches of valve repair or replacement are often associated with risk of thromboembolism, need for anticoagulation, prosthetic endocarditis, and impaired left ventricle function. The cardiovascular hemodynamics model of the present disclosure helps to create ‘what if’ conditions to study variations in different hemodynamic parameters like blood flow, aortic and ventricular pressure, etc. during normal and pathological conditions. An adaptive control system in conjunction with the hemodynamic cardiovascular system (CVS) is provided to handle hemodynamic disbalance during moderate to severe MS conditions. The adaptive controller is hypothesized in line with the neuromodulation approach and modulates left ventricular contractility and vagal tone to counter the symptoms associated with MS.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.