Multifunctional immune cell therapies
US11730763B2 · kind B2 · utility
2Cited by
8References
68Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 14, 2018 |
| Grant date | Aug 22, 2023 |
| Priority date | — |
| Expiry date | May 24, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and their use in directing immune responses to target cells. The compositions have uses that include treating hyperproliferative disorders such as cancer. The provided methods generally include the use of a CAR cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or redirect CAR cell-mediated immune response in vitro and in vivo. In some embodiments, the CAR cell comprises a genetic modification to reduce or eliminate the expression of a targeted antigenic determinant.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.