Pro-cyclic dinucleotides and pro-cyclic dinucleotide conjugates for cytokine induction
US11730817B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 28, 2018 |
| Grant date | Aug 22, 2023 |
| Priority date | — |
| Expiry date | Feb 25, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6889
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a Pro-cyclic dinucleotide (Pro-CDN) comprising a STING agonist cyclic dinucleotide which is coupled to a linker system. The Pro-CDNs of the present invention can be metabolized at a targeted site into CDNs and exert their full immunomodulatory effects at said targeted site. The present invention also provides conjugates wherein a Pro-CDN is conjugated to a Biologically Active Molecule (BAM) such as e.g. a cytotoxic molecule, a lipid, a protein, a peptide, a nucleic acid, a sugar or a PRR ligand. The invention provides also methods related to the use of such compounds to perform their activities at their targeted sites, to exert cytotoxic, cytostatic or immunomodulatory effects, to treat or to prevent diseases such as cancers, immunological disorders or infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.