Patent · US Active

Preparation of functional homocysteine residues in polypeptides and peptides

US11732008B2 · kind B2 · utility

0Cited by

6References

14Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Timothy J. Deming · Summerland, US
Eric G. Gharakhanian · Los Angeles, US

Key dates

Filing date	Apr 27, 2017
Grant date	Aug 22, 2023
Priority date	—
Expiry date	Apr 28, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08G69/48
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Methodology was developed for transformation of methionine residues into homocysteine derivatives. Methionine residues can undergo alkylation reactions at low pH to yield sulfonium ions, which can then be selectively demethylated to give alkyl homocysteine residues. This process tolerates many functional groups.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.