Attenuated strains of oncolytic rhabdovirus and uses thereof in tumor treatment
US11732012B2 · kind B2 · utility
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Key dates
| Filing date | Sep 24, 2020 |
| Grant date | Aug 22, 2023 |
| Priority date | — |
| Expiry date | May 24, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20262
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a modified matrix protein of a vesicular stomatitis virus, wherein the protein has amino acid substitutions at position 21, position 51, position 111 and position 221. Further provided are an attenuated strain of the vesicular stomatitis virus producing the modified matrix protein, a composition containing the attenuated strain, and uses thereof in preparing a drug for killing abnormally proliferating cells, inducing and promoting antitumor immune response, or eliminating immunosuppression in a microenvironment of a tumor tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.