Kinase mutants and uses thereof
US11738049B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | May 24, 2018 |
| Grant date | Aug 29, 2023 |
| Priority date | — |
| Expiry date | Jun 20, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y207/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of designing kinase mutants for reprogramming the sensitivity of a target kinase to some specific inhibitors, methods of reprogramming the sensitivity of a target kinase to some specific inhibitors, wherein those kinase inhibitors have little or no affinity for the wild-type target kinase, vectors or cells expressing said mutated kinases, composition and uses thereof for the prevention and/or treatment of a disease or disorder, in particular cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.