Substituted pyrazlo[3,4-c]pyridines as selective BTK kinase inhibitors

US11739090B2 · kind B2 · utility

Assignee

• JUMBO DRUG BANK CO., LTD. · CN

Inventors

• Chunli Shen · Shanghai, CN
• Xiawei WEI · Tianfu, CN
• Chengde Wu · Shanghai, CN
• Guoping HU · Shanghai, CN
• Ning JIANG · Sichuan, CN
• Wei Zheng · Rockville, US
• Jian Li · Shanghai, CN
• Shuhui CHEN · Shanghai, CN

Key dates

• Filing date: Sep 25, 2020
• Grant date: Aug 29, 2023
• Expiry date: Sep 25, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a class of BTK kinase inhibitor compounds with a high activity and a high selectivity and the use thereof in the preparation of a drug for treating BTK target-related diseases. Specifically, disclosed are a compound shown as formula (I), and an isomer and a pharmaceutically acceptable salt thereof.