Patent · US Active

Growth differentiation factor 15 (GDF-15) polypeptides

US11739131B2 · kind B2 · utility

1Cited by

18References

6Claims

0Family size

Assignee

AMGEN INC. · US

Inventors

Yumei Xiong · Palo Alto, US
Yi Zhang · Nanjing, CN
Jackie Z. Sheng · Thousand Oaks, US
Agnes Eva Hamburger · Newbury Park, US
Murielle Veniant-Ellison · Thousand Oaks, US
Grant Shimamoto · Newbury Park, US
Xiaoshan MIN · Burlingame, US
Zhulun Wang · Palo Alto, US
Jie Tang · Singapore, SG
Gunasekaran Kannan · Daly City, US
Kenneth W. Walker · Newbury Park, US
Bryan D. LEMON · Mountain View, US

Key dates

Filing date	May 17, 2019
Grant date	Aug 29, 2023
Priority date	—
Expiry date	Oct 24, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.