Anti-PD-L1/anti-CD47 bispecific antibody
US11739151B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Dec 1, 2018 |
| Grant date | Aug 29, 2023 |
| Priority date | — |
| Expiry date | Dec 17, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/64
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are an anti-PD-L1/anti-CD47 bispecific antibody that has natural IgG characteristics and is in a highly stable heterodimer form without the heavy chain and light chain being mismatched, and a preparation method therefor. Either the first Fc chain or second Fc chain of the bispecific antibody comprises amino acid substitutions at positions 366 and 399, and the other comprises amino acid substitutions at positions 351, 407 and 409.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.