Methods of making lipid nanoparticles

US11744801B2 · kind B2 · utility

Assignee

• ModernaTX, Inc. · US

Inventors

• Joseph Schariter · Waltham, US
• Kimberly Hassett · Cambridge, US
• Mike Smith · Cambridge, US
• Orn Almarsson · Shrewsbury, US
• Luis Brito · Cambridge, US

Key dates

• Filing date: Aug 31, 2018
• Grant date: Sep 5, 2023
• Expiry date: Aug 31, 2038

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.