Live Salmonella typhi vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof
US11744884B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | May 15, 2018 |
| Grant date | Sep 5, 2023 |
| Priority date | — |
| Expiry date | May 15, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.