Method for preparing cyclodextrin metal organic framework (CD-MOF) stable in aqueous phase

US11744903B2 · kind B2 · utility

Assignee

• Qilu University of Technology · CN

Inventors

• Chao Yuan · Plainsboro, US
• Bo Cui · Shanghai, CN
• Meng Zhao · Beijing, CN
• Lu Lu · Kirkland, US
• Jianpeng Li · Fujian, CN
• Yaqi Liu · Beijing, CN

Key dates

• Filing date: Mar 22, 2023
• Grant date: Sep 5, 2023
• Expiry date: Mar 22, 2043

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/352
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for preparing a cyclodextrin metal organic framework (CD-MOF) stable in aqueous phase, including: dissolving β-cyclodextrin and solid potassium hydroxide in deionized water followed by magnetic stirring and ultrasonic treatment at room temperature, addition of methanol and stirring to obtain a reaction mixture; filtering the reaction mixture with a polytetrafluoroethylene membrane filter in a beaker; placing the beaker in methanol vapor to form a β-CD-MOF crystal; washing the β-CD-MOF crystal with ethanol followed by centrifugation and vacuum drying to obtain β-CD-MOF; preparing a β-CD-MOF-active substance complex by impregnation; and preparing an active substance-loaded β-CD-MOF-Tween 80 complex by physical adsorption modification followed by washing with anhydrous ethanol and vacuum drying.