Thermally sensitive protecting groups for cysteine for peptide cyclization and selective disulfide bond formation
US11746114B2 · kind B2 · utility
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25Claims
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Key dates
| Filing date | Feb 4, 2022 |
| Grant date | Sep 5, 2023 |
| Priority date | — |
| Expiry date | Feb 21, 2042 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.