Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
US11746123B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Jun 22, 2020 |
| Grant date | Sep 5, 2023 |
| Priority date | — |
| Expiry date | Jun 22, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.