SiRNA, medical compositions, and methods for treating type ii diabetes using the same

US11746350B2 · kind B2 · utility

Assignee

• Peking University · CN

Inventors

• Liangyi CHEN · 流花街道, CN
• Wenzhen ZHU · Beijing, CN
• Yi WANG · Hsinchu, TW

Key dates

• Filing date: May 17, 2022
• Grant date: Sep 5, 2023
• Expiry date: May 17, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods for treating a subject are provided. The compositions may include a short interfering RNA (siRNA) molecule comprising a sense RNA strand and an anti-sense RNA strand, the sense and anti-sense RNA strands forming an RNA duplex. The method may include administering a medical composition including an agent to the subject, wherein the agent is configured to reduce uridine 5′-diphospho-glucuronosyltransferase (UGT) levels in the subject. The sense RNA strand or the anti-sense RNA strand may be 15 to 25 nucleotides in length. The sense RNA strand and the anti-sense RNA strand may be 70%-100% complementary.