System and method for formation and detection of immersion fluid boluses on a microscope objective
US11747605B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Apr 23, 2019 |
| Grant date | Sep 5, 2023 |
| Priority date | — |
| Expiry date | Jan 12, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG02B21/0088
- WIPO fieldOptics
- WIPO sectorInstruments
Abstract
Microscope imaging system and method for bolus formation and detection. In an exemplary method, immersion fluid may be delivered onto a front end of an objective of the imaging system to form one or more boluses. Each bolus may have a rounded outer surface intersected by an optical axis defined by the objective. At least a portion of each bolus may be illuminated. Light may be detected from each illuminated bolus to create detection data. A value representing a size of each bolus may be determined using the detection data. Delivery of the immersion fluid may be adjusted, if needed, based on the value(s) determined.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.