Artificial intelligence-based many-to-many base calling
US11749380B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 19, 2021 |
| Grant date | Sep 5, 2023 |
| Priority date | — |
| Expiry date | Nov 14, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06N3/044
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The technology disclosed relates to artificial intelligence-based base calling. The technology disclosed relates to accessing a progression of per-cycle analyte channel sets generated for sequencing cycles of a sequencing run, processing, through a neural network-based base caller (NNBC), windows of per-cycle analyte channel sets in the progression for the windows of sequencing cycles of the sequencing run such that the NNBC processes a subject window of per-cycle analyte channel sets in the progression for the subject window of sequencing cycles of the sequencing run and generates provisional base call predictions for three or more sequencing cycles in the subject window of sequencing cycles, from multiple windows in which a particular sequencing cycle appeared at different positions, using the NNBC to generate provisional base call predictions for the particular sequencing cycle, and determining a base call for the particular sequencing cycle based on the plurality of base call predictions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.