Chitosan and polyethylene glycol copolymers and methods and devices for using same for sealing a vascular puncture
US11751857B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 21, 2017 |
| Grant date | Sep 12, 2023 |
| Priority date | — |
| Expiry date | Jan 4, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/04
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.