Patent · US Active

Cereblon binders for the degradation of ikaros

US11753397B2 · kind B2 · utility

0Cited by

32References

19Claims

0Family size

Assignee

C4 THERAPEUTICS, INC.

Inventors

James A. Henderson · Cambridge, US
Gesine Kerstin Veits · Somerville, US
Minsheng He · Andover, US
Christopher G. Nasveschuk · Stoneham, US
Andrew J. Phillips · Arlington, US
Andrew C. Good · Wallingford, US

Key dates

Filing date	Sep 24, 2020
Grant date	Sep 12, 2023
Priority date	—
Expiry date	Sep 24, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D451/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention provides cereblon binders of Formulas: or pharmaceutically acceptable salts thereof, for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications to treat medical disorders including, but not limited to cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.