Methods for generating functional therapeutic B cells ex-vivo
US11753624B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Oct 6, 2016 |
| Grant date | Sep 12, 2023 |
| Priority date | — |
| Expiry date | May 13, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2537/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The various embodiments of the disclosure relate generally to processes, methods, and systems for generating functional B cells ex vivo. It is particularly useful for ex vivo generation of antigen-specific germinal-center (GC) like B cells that are capable of efficient B cell expansion, immunoglobulin (Ig) class switching/class switching recombination (CSR), expression of germinal B cell phenotypes, antibody secretion, and somatic hypermutation (SHM) and resulting affinity maturation center phenotypes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.