Highly potent acid alpha-glucosidase with enhanced carbohydrates
US11753632B2 · kind B2 · utility
3Cited by
48References
19Claims
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Key dates
| Filing date | Feb 23, 2021 |
| Grant date | Sep 12, 2023 |
| Priority date | — |
| Expiry date | Jun 20, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount of rhGAA containing N-glycans carrying mannose-6-phosphate (M6P) or bis-M6P than conventional rhGAAs, along with low amount of non-phosphorylated high mannose glycans, and low amount of terminal galactose on complex oligosaccharides. Compositions containing the rhGAA, and methods of use are described.
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