PTH compounds with low peak-to-trough ratios

US11759504B2 · kind B2 · utility

Assignee

• ASCENDIS PHARMA BONE DISEASES A/S · DK

Inventors

• Kennett Sprogøe · Rudegård, DK
• Lars Holten-Andersen · Vanløse, DK
• David Karpf · Mountain View, US
• Felix Cleemann · Mainz, DE
• Guillaume Maitro · Mannheim, DE
• Mathias Krusch · Hirschhorn, DE
• Thomas Wegge · Heidelberg, DE
• Joachim Zettler · Heidelberg, DE

Key dates

• Filing date: Sep 28, 2017
• Grant date: Sep 19, 2023
• Expiry date: Sep 28, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P5/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a pharmaceutical composition comprising a PTH compound, wherein after subcutaneous administration the pharmacokinetic profile of the PTH compound exhibits a peak to trough ratio of less than 4 within one injection interval.