Method of preparing a DON prodrug from L-pyroglutamic acid

US11760723B2 · kind B2 · utility

Assignee

• DRACEN PHARMACEUTICALS, INC. · US

Inventors

• Jon Philip Lawson · Wildwood, US
• Robert C. Wild · Murrieta, US
• Yiyang Shao · Beijing, CN
• Jinxiao Chu · Beijing, CN
• Jinchao Weng · Beijing, CN
• Pavel Majer · Sykesville, US

Key dates

• Filing date: Feb 11, 2020
• Grant date: Sep 19, 2023
• Expiry date: May 4, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides a method of preparing a compound of Formula I, wherein R1 is C1-C4 alkyl; R2 is C1-C4 alkyl; and R3 is selected from the group consisting of C1-C6 alkyl, (aryl)alkyl, and (heteroaryl)alkyl in >95% chemical purity and >95% enantiomeric excess.