Mitragynine analogs for the treatment of pain, mood disorders and substance use disorders

US11760758B2 · kind B2 · utility

Assignees

• The Trustees of Columbia University in the City of New York · US
• The Research Foundation for Mental Hygiene, Inc · US
• Sloan Kettering Institute for Cancer Research · US

Inventors

• Andrew Carry Kruegel · New York, US
• Dalibor Sames · New York, US
• Srijita Bhowmik · New York, US
• Vaclav Havel · Opava, CZ
• Juraj Galeta · New York, US
• Jonathan A. Javitch · Dobbs Ferry, US
• Susruta Majumdar · Chesterfield, US

Key dates

• Filing date: Feb 16, 2021
• Grant date: Sep 19, 2023
• Expiry date: Feb 16, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.