Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US11761011B2 · kind B2 · utility
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Key dates
| Filing date | Mar 22, 2021 |
| Grant date | Sep 19, 2023 |
| Priority date | — |
| Expiry date | Mar 22, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification.
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