Patent · US Active

Splice variants associated with neomorphic SF3B1 mutants

US11761045B2 · kind B2 · utility

0Cited by

6References

25Claims

0Family size

Assignee

Eisai R&D Management Co., Ltd. · JP

Inventors

Lihua Yu · Acton, US
Kian Huat Lim · Burlington, US
Jacob D. Feala · Washington, US
Silvia Buonamici · Boston, US
Yoshiharu Mizui · Boston, US
Peter Smith · Arlington, US
Ping Zhu · Boxborough, US
Eunice Sun Park · Arlington, US
Michael W. Seiler · Belmont, US
Marco Peter Fekkes · Waltham, US

Key dates

Filing date	Nov 16, 2020
Grant date	Sep 19, 2023
Priority date	—
Expiry date	Nov 16, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/158
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.