Methods of selecting therapeutic molecules
US11761951B2 · kind B2 · utility
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37References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 4, 2016 |
| Grant date | Sep 19, 2023 |
| Priority date | — |
| Expiry date | May 24, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/341
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.