Cleavable conjugates of catechol compounds and water-soluble polymers and methods of treatment using the same
US11766432B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 27, 2019 |
| Grant date | Sep 26, 2023 |
| Priority date | — |
| Expiry date | Jul 27, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G73/0233
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.