Compounds and methods for inhibiting viral replication and methods of treating and preventing flaviviral infections

US11767303B2 · kind B2 · utility

Assignees

• HEALTH RESEARCH, INC. · US
• The Board of Regents of the University of Texas System · US
• Arizona Board of Regents on Behalf of the University of Arizona · US

Inventors

• Hongmin Li · Daguantang, CN
• Zhong Li · Lo Wu, CN
• Jia Zhou · Galveston, US
• Jimin Xu · Galveston, US
• Qing Zhang · Seattle, US

Key dates

• Filing date: Jul 23, 2021
• Grant date: Sep 26, 2023
• Expiry date: Jul 23, 2041

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.