Non-uniform excitation field-based method and system for performing magnetic nanoparticle imaging

US11771336B2 · kind B2 · utility

Assignee

• Institute of Automation, Chinese Academy of Sciences · CN

Inventors

• Jie Tian · Shanghai, CN
• Yanjun Liu · Shanghai, CN
• Hui Hui · Beijing, CN
• Lin Yin · Fremont, US
• Xin Feng · Canton, US

Key dates

• Filing date: Jul 7, 2022
• Grant date: Oct 3, 2023
• Expiry date: Jul 7, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/54
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present disclosure belongs to a field of biomedical imaging technology, and in particularly to a non-uniform excitation field-based method and system for performing a magnetic nanoparticle imaging. The present disclosure includes: separating the non-uniform excitation field into independent space and current time functions by a spatialtemporal separation method; calculating a normalized signal peak through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak and an imaging subunit volume; and quantitatively reconstructing a spatial distribution of a nanoparticle by combining the normalized signal peak, a non-uniform spatial function of the excitation field and the reconstruction mathematical model, so as to achieve the magnetic nanoparticle imaging of a to-be-reconstructed object.