Poly(ester urea) adhesion barriers for use in the treatment of hernia-mesh repair
US11771543B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 7, 2019 |
| Grant date | Oct 3, 2023 |
| Priority date | — |
| Expiry date | Feb 3, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/34
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
In various embodiments, the present invention is directed to a degradable poly(ester urea) (PEU)-based adhesion barrier, particularly suitable for use in connection with surgical mesh repair in the treatment of hernias and other soft tissue injuries comprising an amino acid based poly(ester urea) backbone and one or more zwitterionic side chains connected to the amino acid based poly(ester urea) backbone through a sulfide bond. In some other embodiments, the present invention is directed to method of making the PEU-based adhesion barriers comprising: preparing an amino acid based PEU polymer or terpolymer having one or more allyl functional groups; preparing a thiol functionalized zwitterionic compound; and reacting the allyl functionalized PEU polymer or terpolymer with the thiol functionalized zwitterionic compound to form a degradable PEU-based adhesion barrier having an amino acid based PEU backbone having zwitterionic side chains.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.