Flavonoid polyphenol drug self-emulsifying composition, preparation method therefor, pharmaceutical composition thereof and application thereof

US11771660B2 · kind B2 · utility

Assignees

• BEIJING WEHAND-BIO PHARMACEUTICAL CO., LTD · CN
• INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES & PEKING UNION MEDICAL COLLEGE · CN

Inventors

• Yuling Liu · Tianjin, CN
• Hengfeng Liao · Beijing, CN
• Yue Gao · 红钢城街道, CN
• Wujun Dong · Beijing, CN
• Zhihua Liu · Beijing, CN
• Bangyuan Wang · Beijing, CN
• Yun ZHANG · Lanzhou, CN
• Yu Feng · Cliffside Park, US
• Junzhuo Zhou · Beijing, CN
• Lu Liu · 东风镇, CN
• Jun YE · Beijing, CN
• Yanfang YANG · Beijing, CN
• Xuejun Xia · Beijing, CN

Key dates

• Filing date: Apr 8, 2020
• Grant date: Oct 3, 2023
• Expiry date: Apr 19, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K36/539
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A flavonoid polyphenol drug self-emulsifying composition based on a flavonoid polyphenol drug-phospholipid complex being used as an intermediate, the composition comprising a flavonoid polyphenol drug-phospholipid complex, an oil phase, an emulsifier and a co-emulsifier, the flavonoid polyphenol drug comprising one or more selected from baicalein, proanthocyanidin, quercetin, curcumin and resveratrol. The described self-emulsifying composition has the beneficial effects of good stability, a high amount of drug loading, high bioavailability, and so on.