Method for preparing high-load oral paclitaxel capsule for slow release in colon
US11771676B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 27, 2023 |
| Grant date | Oct 3, 2023 |
| Priority date | — |
| Expiry date | Mar 27, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5036
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a method for preparing high-load oral paclitaxel capsule for a slow release in colon, belonging to the field of porous starch drug loading. The preparation method of the present disclosure includes the following steps: (1) dripping an ethanol solution of paclitaxel into a water phase and drying the solution to obtain an amorphous paclitaxel microsphere; (2) redissolving the paclitaxel microsphere prepared in step (1) in the ethanol solution, dispersing porous starch in the ethanol solution for adsorption, volatilizing a solvent in an oven, washing the porous starch with the ethanol solution to remove unadsorbed paclitaxel, and centrifuging same to obtain a precipitate, namely the porous starch loaded with paclitaxel; and (3) dispersing the porous starch loaded with paclitaxel prepared in step (2) in a chitosan solution, dropwise adding the solution into a phytic acid solution, and stirring the solution for 4 hours to obtain a coated capsule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.